Social decline in the psychosis prodrome: Predictor potential and heterogeneity of outcome

While an established clinical outcome of high importance, social functioning has been emerging as possibly having a broader significance to the evolution psychosis and long term disability. In current study we explored association between decline, conversion psychosis, functional in individuals at risk (CHR) for psychosis. 585 subjects collected North American Prodrome Longitudinal Study (NAPLS2) were divided into 236 Healthy Controls (HCs), CHR that developed (CHR + C, N = 79), or those did not (Non-Converters, CHR-NC, 270). C further experienced atypical decline prior baseline (beyond typical impairment levels) when min-to-late adolescence C-SD, 39) undergoing C-NSD, 40). Patterns poor outcomes varied across subgroups: CHR-NC (Poor Social 36.3%, Role 42.2%) through C-NSD 50%, Poor 67.5%) C-SD 76.9%, 89.7%) functioning. The two Converter subgroups had comparable positive symptoms baseline. At 12 months, group stabilized, but levels remained significantly lower than other subgroups. demonstrates pre-baseline mid-to-late predicts addition, found this converters is strongly associated with especially overall poorer prognosis. functioning, contrast, shown similar predictor potential, rather appears be illness indicator worsens over time.